Rescuing Cardiac Malfunction

Rescuing cardiac malfunction: the roles of the chaperone-like small heat shock proteins.

In response to various hypertrophic stimuli, the heart undergoes alterations in structure and function. One mechanism by which the heart adapts to physiological and pathological stimuli is an increase in size of individual cardiac myocytes, and when those stimuli are removed, the size of the myocytes can decrease. Modulation of cardiac size thus requires a very careful balance between protein s...

Pacemaker Malfunction Attributed to Multidetector Cardiac Computed Tomography.

Circulation. 2016;134:e15. DOI: 10.1161/CIRCULATIONAHA.116.022571 July 19, 2016 In Response: We thank Verheyen et al for their thoughtful comments on the case we published1 concerning pacemaker inhibition during the performance of cardiac computed tomography. We would like to add some of the details requested so that the context of this event can be better understood, and therefore, its broader...

Akt2 knockout preserves cardiac function in high-fat diet-induced obesity by rescuing cardiac autophagosome maturation.

Rescuing doctors in distress.

burnout or depression among physicians: financial cuts, relentless night shifts, long hours of work, overwhelming responsibility, dealing with life-threatening conditions, distress over the limitations of medical care, or just working conditions that have worsened in recent decades as a result of increasing time pressure, competition, explosion of knowledge, administrative loads or lack of auto...

Melatonin mitigates mitochondrial malfunction.

Melatonin, or N-acetyl-5-methoxytryptamine, is a compound derived from tryptophan that is found in all organisms from unicells to vertebrates. This indoleamine may act as a protective agent in disease conditions such as Parkinson's, Alzheimer's, aging, sepsis and other disorders including ischemia/reperfusion. In addition, melatonin has been proposed as a drug for the treatment of cancer. These...